(2R,3S)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
97%
science Other reagents with same CAS 129821-76-7
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description Product Description
Widely used in oligonucleotide synthesis, this compound serves as a phosphoramidite building block for introducing modified sugar moieties into DNA or RNA strands. Its primary application lies in the solid-phase synthesis of custom sequences, where it enables the incorporation of specific stereochemical configurations at the phosphite linkage. The bis(4-methoxyphenyl)(phenyl)methoxy group acts as a protecting group that ensures high coupling efficiency and stability during automated synthesis. The (2-cyanoethyl) group facilitates rapid deprotection under mild basic conditions, making it ideal for high-throughput production of antisense oligonucleotides, siRNA, and diagnostic probes. Its stereo-defined structure supports research in nucleic acid therapeutics where precise three-dimensional architecture is critical for biological activity.
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