(2S,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-cyclohexylpyrrolidine-2-carboxylic acid
97%
Reagent
Code: #232477
CAS Number
1820571-03-6
science Other reagents with same CAS 1820571-03-6
blur_circular Chemical Specifications
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Molecular Information
Weight
419.51 g/mol
Formula
C₂₆H₂₉NO₄
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Registry Numbers
MDL Number
MFCD26793611
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Physical Properties
Boiling Point
608.7±48.0 °C(Predicted)
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Widely used in peptide synthesis and medicinal chemistry, this compound serves as a chiral building block for the development of protease inhibitors and other biologically active molecules. Its structure incorporates both a fluorenylmethyloxycarbonyl (Fmoc) protecting group and a sterically defined pyrrolidine scaffold, making it valuable in solid-phase peptide synthesis. The presence of the cyclohexyl substituent enhances lipophilicity and influences conformational rigidity, which can improve binding selectivity and metabolic stability in drug design. It is particularly useful in the synthesis of enzyme inhibitors where stereochemistry plays a critical role in activity. Additionally, its Fmoc group allows for mild deprotection conditions, compatible with a wide range of functional groups, facilitating its use in multi-step syntheses of complex pharmaceuticals.
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