Used as a cleavable crosslinker in bioconjugation, particularly in antibody-drug conjugates (ADCs) and protein labeling. Its sulfonate group enhances water solubility, allowing reactions to proceed efficiently in aqueous environments without organic solvents. The disulfide bond in its structure enables controlled release of payloads in reducing environments, such as inside cells, making it valuable for targeted drug delivery. Commonly employed in the development of therapeutic conjugates where precise release of active compounds is required. Also applied in proteomics research for reversible immobilization of biomolecules.