Used in targeted protein degradation technologies, particularly as a linker component in proteolysis-targeting chimeras (PROTACs). It enables the recruitment of E3 ubiquitin ligases to facilitate the degradation of disease-related proteins. Its structure supports conjugation between a target-binding ligand and an E3 ligase ligand, promoting ubiquitination and subsequent proteasomal degradation of the target protein. Commonly applied in research for oncology, neurodegenerative diseases, and other conditions where selective protein knockdown is desired. Also utilized in the development of molecular glues and bifunctional degraders due to its stability and spacer functionality.