SGI-1027 is primarily used as a research compound in epigenetics studies due to its ability to inhibit DNA methyltransferases (DNMTs). It is employed in cellular and molecular biology experiments to demethylate DNA, which helps in reactivating silenced tumor suppressor genes in cancer cells. This makes it a valuable tool for studying gene expression regulation and the role of DNA methylation in diseases like cancer. Researchers also use SGI-1027 to explore potential therapeutic strategies for reversing abnormal epigenetic modifications, particularly in leukemia and other malignancies. Its application remains confined to laboratory research and is not used clinically.