Simulanol is widely used in the cosmetic and personal care industry as an emollient and skin-conditioning agent. It helps improve the texture and spreadability of creams, lotions, and serums, providing a smooth, non-greasy feel upon application. Due to its moisturizing properties, it is commonly found in formulations designed for dry or sensitive skin.

In pharmaceuticals, Simulanol serves as a carrier or excipient in topical preparations, enhancing the delivery of active ingredients through the skin. Its compatibility with a range of other formulation components makes it suitable for use in both oil-based and water-based products.

It is also utilized in the production of synthetic lubricants for light industrial applications, where thermal stability and low volatility are required. Its mild odor and low irritation potential further support its use in consumer-facing products.