Used in the synthesis of PROTACs (Proteolysis Targeting Chimeras), this compound serves as a key intermediate for recruiting E3 ubiquitin ligases, particularly those in the von Hippel-Lindau (VHL) complex. Its structure enables selective binding to VHL when deprotected, making it valuable in developing targeted protein degraders for cancer and other diseases. The Boc-protected amine allows for controlled coupling in multi-step peptide-like syntheses, while the carboxylic acid moiety facilitates linker attachment to warhead molecules. Commonly applied in medicinal chemistry research for optimizing degradation efficiency and pharmacokinetic properties of novel therapeutics.