Used in PROTAC (Proteolysis Targeting Chimeras) technology to facilitate targeted protein degradation. Acts as a linker with an azide functional group that enables click chemistry for conjugation to complementary moieties, such as alkyne-bearing ligands. The PEG6 spacer enhances solubility and provides optimal distance between the target-binding and E3 ligase-binding components of the PROTAC molecule. Its stereochemistry supports improved binding selectivity and stability, contributing to efficient formation of the ternary complex required for ubiquitination and subsequent degradation of disease-related proteins. Commonly applied in drug discovery and development for cancer, neurodegenerative diseases, and other conditions involving undruggable targets.