Solvent Blue 43 is widely used as a dye in industrial applications where color tracing and identification are essential. It is commonly added to fuels and oils to enable visual tracking of fuel composition, detect adulteration, and differentiate between various grades or types of petroleum products. Due to its solubility in non-polar solvents, it is particularly effective in hydrocarbon-based systems.

The dye is also employed in refrigeration and air conditioning systems, where it helps technicians trace refrigerant flow and identify leaks. When mixed with refrigerants or lubricants, Solvent Blue 43 imparts a distinct blue color that becomes visible under UV or blue light, aiding in the detection of small leaks that would otherwise be difficult to locate.

Additionally, it is used in laboratory settings as a coloring agent in solvent-based experiments and in the formulation of specialty inks and coatings where a stable, oil-soluble blue dye is required. Its thermal stability and resistance to fading make it suitable for applications exposed to varying temperatures and light conditions.