Used as a reagent in organic synthesis, particularly in trifluoromethanesulfonylation reactions. It serves as a source of the triflyl (SO₂CF₃) group, which is valuable for introducing electron-withdrawing moieties into target molecules. Commonly applied in the preparation of sulfonate esters and sulfonamides, which are key intermediates in pharmaceuticals and agrochemicals. Also utilized in catalysis and materials science where strong electron-withdrawing groups enhance stability or modify reactivity. Its reactivity makes it suitable for forming carbon–heteroatom bonds under mild conditions.