TFMO 2 is widely used as a fluorinating agent in organic synthesis, particularly in the introduction of trifluoromethyl groups into pharmaceutical compounds. It enables selective and efficient trifluoromethylation under mild reaction conditions, making it valuable in drug development where metabolic stability and bioavailability are critical. Its reactivity profile allows compatibility with a range of functional groups, reducing the need for protecting groups and streamlining synthetic routes. It is also employed in the preparation of agrochemicals and functional materials requiring fluorinated building blocks.