Used in biochemical and biomedical research as a nucleoside analog, 6-Thio-dG is primarily investigated for its potential in cancer therapy. It gets incorporated into DNA during replication, especially in rapidly dividing cells, leading to DNA damage and cell death in tumor cells. It shows particular promise in targeting telomerase-positive cancer cells by disrupting telomere maintenance. Additionally, 6-Thio-dG has been studied for its immunomodulatory effects, potentially enhancing the recognition of cancer cells by the immune system. Its ability to induce oxidative stress in cancer cells further supports its role in therapeutic strategies. Research also explores its use in combination with other anticancer agents to improve treatment efficacy.