Used in dermatology as a topical treatment for plaque psoriasis and atopic dermatitis. It functions by activating the aryl hydrocarbon receptor (AhR), which helps modulate immune responses and reduce inflammation in the skin. Its anti-inflammatory properties make it effective in improving skin lesions and symptoms like redness, scaling, and itching. Tapinarof is valued for its non-steroidal mechanism, offering a treatment option without the side effects associated with long-term corticosteroid use. It is applied once daily and has shown sustained efficacy with favorable tolerability in clinical studies.