Used as a key reagent in sulfur fluoride exchange (SuFEx) click chemistry, enabling rapid and selective covalent coupling with nucleophilic residues like phenols or amines in biomolecules. Its boronate ester group allows participation in Suzuki-Miyaura cross-coupling reactions, making it valuable for constructing biaryl frameworks in pharmaceuticals and functional materials. Commonly employed in bioconjugation, chemical biology probes, and the synthesis of covalent inhibitors due to its dual reactivity and stability under various reaction conditions.