Used in epigenetic research as a potent and selective inhibitor of G9a and GLP methyltransferases, UNC0642 helps modulate histone methylation, particularly H3K9me2. This compound is valuable for studying gene silencing, chromatin remodeling, and cellular differentiation. Its cell permeability and reversible binding make it suitable for in vitro and in vivo studies exploring the role of G9a/GLP in cancer, stem cell biology, and neurological disorders. Researchers also use it to probe the therapeutic potential of targeting epigenetic regulators in diseases involving aberrant gene expression.