VH 032 amide-alkylC7-amine dihydrochloride is a derivative of the VH032 ligand, designed for use in proteolysis-targeting chimeras (PROTACs). It serves as a selective binder for the Von Hippel-Lindau (VHL) E3 ubiquitin ligase, facilitating the recruitment of target proteins for ubiquitination and proteasomal degradation. This compound inhibits the VHL-HIF1α protein-protein interaction, stabilizing hypoxia-inducible factor (HIF) and modulating cellular responses to hypoxia, which is relevant in cancer, inflammation, and angiogenesis research. The amine-functionalized C7 alkyl linker enables facile conjugation to warheads or other moieties, making it valuable in the synthesis of bifunctional PROTACs and chemical probes for studying protein degradation pathways. Due to its cell permeability and stability, it is employed in cellular assays to investigate effects on gene expression, cell proliferation, and therapeutic potential in pharmaceutical development.