huCLDN6-HEK293 is primarily used in biomedical research as a cell-based assay system for studying human claudin-6 (CLDN6) expression and function. It serves as a critical tool in oncology and immunotherapy development, particularly in the screening and validation of monoclonal antibodies, chimeric antigen receptor (CAR) T cells, and other targeted therapies directed against CLDN6—a protein often overexpressed in various cancers such as testicular, ovarian, and endometrial carcinomas. The HEK293 cell line stably expressing human CLDN6 allows consistent and reliable antigen presentation, making it ideal for flow cytometry, binding assays, and cytotoxicity studies. It is also employed in target validation during early drug discovery to assess specificity and potency of CLDN6-targeting biologics. Due to its human origin and robust protein expression, this cell system supports translational research aimed at developing safe and effective cancer treatments.