Used in bone metabolism studies to measure type I collagen degradation, particularly in research on osteoporosis, rheumatoid arthritis, and bone turnover in cancer metastasis. Helps assess bone resorption by detecting ICTP fragments released during collagen breakdown. Commonly applied in clinical and preclinical settings to evaluate the effectiveness of anti-resorptive therapies like bisphosphonates. Also used in monitoring disease progression and response to treatment in liver fibrosis and other connective tissue disorders.