Used in clinical and research settings to measure pepsinogen I levels in biological samples, aiding in the assessment of gastric mucosal health. Helps in the diagnosis and monitoring of atrophic gastritis, a condition linked to increased risk of gastric cancer. Supports studies on Helicobacter pylori infection and its impact on gastric function. Enables non-invasive evaluation of gastric acid secretion and mucosal integrity, particularly in large-scale epidemiological studies. Commonly used in biomarker validation and gastrointestinal disease research.