Used in research to quantify full-length and caspase-cleaved cytokeratin 18 fragments in cell culture supernatants or tissue extracts. Helps assess epithelial cell death, particularly in studies of liver diseases such as NASH, drug-induced liver injury, and apoptosis in cancer models. Commonly applied in preclinical drug development to evaluate hepatotoxicity and treatment efficacy. Also utilized in studies of tissue damage and regeneration where epithelial integrity is compromised.