Used in research to detect and quantify full-length and caspase-cleaved fragments of cytokeratin 18 in serum or plasma, the kit serves as a biomarker tool for assessing epithelial cell death. It is widely applied in studies of liver diseases such as non-alcoholic steatohepatitis (NASH), drug-induced liver injury, and viral hepatitis, where elevated levels correlate with disease severity and treatment response. Researchers also use it in oncology to monitor tumor cell apoptosis during chemotherapy and in transplantation to evaluate graft injury. The assay supports investigation into cellular turnover and tissue damage in various clinical and preclinical settings.