Used in biomedical research to quantify sorbitol dehydrogenase levels in human samples, aiding in the study of metabolic disorders such as diabetes. Helps assess sorbitol pathway activity, particularly in tissues like liver, kidney, and nerve cells where SDH plays a role in glucose metabolism. Supports investigation into diabetic complications including neuropathy, retinopathy, and nephropathy by providing a reliable measure of enzyme concentration in serum, plasma, or tissue homogenates. Commonly used in clinical labs and research settings for biomarker validation and monitoring disease progression.