Acelarin
10mM in DMSO
Reagent
Code: #134037
CAS Number
840506-29-8
blur_circular Chemical Specifications
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Molecular Information
Weight
580.47 g/mol
Formula
C₂₅H₂₇F₂N₄O₈P
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Storage & Handling
Storage
-20°C
description Product Description
Used in the treatment of various solid tumors, particularly in advanced or metastatic cancers such as pancreatic, ovarian, and non-small cell lung cancer. It functions as a prodrug of gemcitabine, designed to overcome resistance mechanisms that limit the effectiveness of gemcitabine in some patients. By improving cellular uptake and retention, it enhances cytotoxic activity against tumor cells. It is under clinical investigation for its potential to provide better therapeutic outcomes in patients who have failed prior gemcitabine-based therapies. Its application is primarily in oncology, especially in settings where conventional nucleoside analogs show limited efficacy.
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Acelarin
Used in the treatment of various solid tumors, particularly in advanced or metastatic cancers such as pancreatic, ovarian, and non-small cell lung cancer. It functions as a prodrug of gemcitabine, designed to overcome resistance mechanisms that limit the effectiveness of gemcitabine in some patients. By improving cellular uptake and retention, it enhances cytotoxic activity against tumor cells. It is under clinical investigation for its potential to provide better therapeutic outcomes in patients who have failed prior gemcitabine-based therapies. Its application is primarily in oncology, especially in settings where conventional nucleoside analogs show limited efficacy.
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