Arg-Gly-Asp (RGD) is widely used in biomedical research and regenerative medicine due to its ability to mimic cell adhesion sites in extracellular matrix proteins. It is commonly incorporated into synthetic biomaterials to enhance cell attachment, spreading, and tissue integration. RGD sequences are especially valuable in tissue engineering scaffolds, where they promote the binding of cells through integrin receptors, supporting wound healing and tissue regeneration. In drug delivery, RGD peptides are used to target specific cells, such as tumor cells and activated endothelial cells in angiogenesis, enabling selective delivery of therapeutic agents. This targeting ability makes RGD a key component in developing anti-cancer drugs and imaging probes for tumors. It is also applied in diagnostic imaging, where RGD-conjugated imaging agents help visualize blood vessel formation in tumors and areas of inflammation. Additionally, RGD-based coatings are used on medical implants and stents to improve biocompatibility and reduce adverse reactions by encouraging desirable cell interactions.