Used in research to modulate the activity of WNK kinases, which play a key role in regulating ion transport and blood pressure. This inhibitor targets an allosteric site, offering high selectivity and enabling precise control over kinase function in cellular studies. It is valuable for investigating pathways related to hypertension, electrolyte balance, and rare genetic disorders like pseudohypoaldosteronism type II. Potential therapeutic development is being explored for cardiovascular and renal diseases.