BMN 673

≥98%

Reagent Code: #144604
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CAS Number 1207456-01-6

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scatter_plot Molecular Information
Weight 380.35 g/mol
Formula C₁₉H₁₄F₂N₆O
inventory_2 Storage & Handling
Storage Room temperature, dry, sealed

description Product Description

BMN 673 is a potent inhibitor of the PARP enzyme family, particularly PARP1 and PARP2, which play key roles in DNA repair mechanisms. Its primary application lies in cancer therapy, especially in tumors with deficiencies in homologous recombination repair pathways, such as those with BRCA1 or BRCA2 mutations. By inhibiting PARP, BMN 673 induces synthetic lethality in these cancer cells, leading to selective tumor cell death while sparing normal cells. It has shown promising activity in preclinical models of breast, ovarian, and prostate cancers. Additionally, BMN 673 is being investigated for use in combination with other DNA-damaging agents like chemotherapy or radiation to enhance their antitumor effects. Its high potency and favorable pharmacokinetic profile make it a candidate for targeted therapies in precision oncology.

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Size Availability Unit Price Quantity
inventory 10mg
10-20 days ฿3,210.00
inventory 50mg
10-20 days ฿10,890.00
BMN 673
BMN 673 is a potent inhibitor of the PARP enzyme family, particularly PARP1 and PARP2, which play key roles in DNA repair mechanisms. Its primary application lies in cancer therapy, especially in tumors with deficiencies in homologous recombination repair pathways, such as those with BRCA1 or BRCA2 mutations. By inhibiting PARP, BMN 673 induces synthetic lethality in these cancer cells, leading to selective tumor cell death while sparing normal cells. It has shown promising activity in preclinical models of breast, ovarian, and prostate cancers. Additionally, BMN 673 is being investigated for use in combination with other DNA-damaging agents like chemotherapy or radiation to enhance their antitumor effects. Its high potency and favorable pharmacokinetic profile make it a candidate for targeted therapies in precision oncology.
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