3'-Chloro-4'-methyl-[1,1'-biphenyl]-2-carbonitrile
98%
Reagent
Code: #166721
CAS Number
442670-45-3
blur_circular Chemical Specifications
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Molecular Information
Weight
227.69 g/mol
Formula
C₁₄H₁₀ClN
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Registry Numbers
MDL Number
MFCD07779319
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like valsartan and related sartan-class medications. Its structure allows for effective coupling in biphenyl-based pharmaceuticals, enhancing binding affinity to the AT1 receptor. Commonly employed in API manufacturing due to its reactive nitrile group and halogenated aromatic ring, facilitating further functionalization through cross-coupling reactions. Also utilized in research for developing new cardiovascular therapeutics.
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3'-Chloro-4'-methyl-[1,1'-biphenyl]-2-carbonitrile
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like valsartan and related sartan-class medications. Its structure allows for effective coupling in biphenyl-based pharmaceuticals, enhancing binding affinity to the AT1 receptor. Commonly employed in API manufacturing due to its reactive nitrile group and halogenated aromatic ring, facilitating further functionalization through cross-coupling reactions. Also utilized in research for developing new cardiovascular therapeutics.
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