4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-5-BORONIC ACID PINACOL ESTER
97%
Reagent
Code: #166907
CAS Number
1072145-24-4
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Molecular Information
Weight
278.54 g/mol
Formula
C₁₃H₁₆BClN₂O₂
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Registry Numbers
MDL Number
MFCD09965897
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment. Its boronic ester functionality enables participation in Suzuki-Miyaura cross-coupling reactions, allowing efficient formation of carbon-carbon bonds in complex heterocyclic systems. Commonly employed in medicinal chemistry for lead optimization due to its ability to introduce the pyrrolopyridine scaffold, which enhances binding affinity and selectivity toward biological targets. Also utilized in the preparation of analogs for structure-activity relationship (SAR) studies in drug discovery programs targeting inflammatory and oncological diseases.
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4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-5-BORONIC ACID PINACOL ESTER
Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of kinase inhibitors for cancer treatment. Its boronic ester functionality enables participation in Suzuki-Miyaura cross-coupling reactions, allowing efficient formation of carbon-carbon bonds in complex heterocyclic systems. Commonly employed in medicinal chemistry for lead optimization due to its ability to introduce the pyrrolopyridine scaffold, which enhances binding affinity and selectivity toward biological targets. Also utilized in the preparation of analogs for structure-activity relationship (SAR) studies in drug discovery programs targeting inflammatory and oncological diseases.
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