(E)-4,4,4-Trifluoro-3-methyl-2-butenoic acid
97%
Reagent
Code: #184812
CAS Number
400-28-2
blur_circular Chemical Specifications
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Molecular Information
Weight
154.09 g/mol
Formula
C₅H₅F₃O₂
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Registry Numbers
MDL Number
MFCD00014374
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals due to its reactive α,β-unsaturated carbonyl structure and the electron-withdrawing effect of the trifluoromethyl group. Its conjugated system allows for Michael addition reactions, making it valuable in building complex fluorinated molecules. Commonly employed in the development of bioactive compounds where enhanced metabolic stability and membrane permeability are desired. Also utilized in the preparation of fluorinated analogs of natural products for structure-activity relationship studies.
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(E)-4,4,4-Trifluoro-3-methyl-2-butenoic acid
Used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals due to its reactive α,β-unsaturated carbonyl structure and the electron-withdrawing effect of the trifluoromethyl group. Its conjugated system allows for Michael addition reactions, making it valuable in building complex fluorinated molecules. Commonly employed in the development of bioactive compounds where enhanced metabolic stability and membrane permeability are desired. Also utilized in the preparation of fluorinated analogs of natural products for structure-activity relationship studies.
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