4-Hydroxy-6-(trifluoromethyl)pyrimidine
97%
Reagent
Code: #194568
CAS Number
1546-78-7
blur_circular Chemical Specifications
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Molecular Information
Weight
164.09 g/mol
Formula
C₅H₃F₃N₂O
thermostat
Physical Properties
Melting Point
169-171°C
Boiling Point
229°C
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. Its structure supports binding to enzyme active sites, enhancing selectivity and potency. Also employed in agrochemicals to improve metabolic stability and bioavailability in crop protection agents. The trifluoromethyl group contributes to lipophilicity and resistance to oxidative degradation, making it valuable in designing compounds with improved pharmacokinetic profiles.
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4-Hydroxy-6-(trifluoromethyl)pyrimidine
Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. Its structure supports binding to enzyme active sites, enhancing selectivity and potency. Also employed in agrochemicals to improve metabolic stability and bioavailability in crop protection agents. The trifluoromethyl group contributes to lipophilicity and resistance to oxidative degradation, making it valuable in designing compounds with improved pharmacokinetic profiles.
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