2-(1H-Tetrazol-5-yl)-5-(trifluoromethyl)pyridine
90%
Reagent
Code: #196734
CAS Number
175334-70-0
blur_circular Chemical Specifications
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Molecular Information
Weight
215.14 g/mol
Formula
C₇H₄F₃N₅
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Registry Numbers
MDL Number
MFCD00205782
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Storage & Handling
Storage
2-8°C, dry
description Product Description
Used in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like candesartan and related sartan-class medications. The tetrazole ring acts as a bioisostere for the carboxylic acid group, enhancing metabolic stability and improving receptor binding affinity. Its lipophilic trifluoromethylpyridine moiety contributes to increased membrane permeability and prolonged pharmacological activity. Commonly employed in pharmaceutical research and development for optimizing drug candidates targeting hypertension and cardiovascular diseases.
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2-(1H-Tetrazol-5-yl)-5-(trifluoromethyl)pyridine
Used in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like candesartan and related sartan-class medications. The tetrazole ring acts as a bioisostere for the carboxylic acid group, enhancing metabolic stability and improving receptor binding affinity. Its lipophilic trifluoromethylpyridine moiety contributes to increased membrane permeability and prolonged pharmacological activity. Commonly employed in pharmaceutical research and development for optimizing drug candidates targeting hypertension and cardiovascular diseases.
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