2-(1H-Tetrazol-5-yl)-5-(trifluoromethyl)pyridine

90%

Reagent Code: #196734
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CAS Number 175334-70-0

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Weight 215.14 g/mol
Formula C₇H₄F₃N₅
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MDL Number MFCD00205782
inventory_2 Storage & Handling
Storage 2-8°C, dry

description Product Description

Used in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like candesartan and related sartan-class medications. The tetrazole ring acts as a bioisostere for the carboxylic acid group, enhancing metabolic stability and improving receptor binding affinity. Its lipophilic trifluoromethylpyridine moiety contributes to increased membrane permeability and prolonged pharmacological activity. Commonly employed in pharmaceutical research and development for optimizing drug candidates targeting hypertension and cardiovascular diseases.

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Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿2,950.00
inventory 250mg
10-20 days ฿6,690.00
inventory 1g
10-20 days ฿20,080.00
2-(1H-Tetrazol-5-yl)-5-(trifluoromethyl)pyridine
Used in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like candesartan and related sartan-class medications. The tetrazole ring acts as a bioisostere for the carboxylic acid group, enhancing metabolic stability and improving receptor binding affinity. Its lipophilic trifluoromethylpyridine moiety contributes to increased membrane permeability and prolonged pharmacological activity. Commonly employed in pharmaceutical research and development for optimizing drug candidates targeting hypertension and cardiovascular diseases.
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