Okanin is a natural chalcone compound found in plants such as Bidens pilosa (blackjack). It has gained attention for its significant biological activities. It exhibits strong anti-inflammatory effects by inhibiting pro-inflammatory cytokines and enzymes like COX-2, making it a candidate for managing inflammatory diseases. Okanin also shows potent antioxidant properties, helping to neutralize free radicals and reduce oxidative stress, which is linked to chronic conditions like diabetes and neurodegenerative disorders. Studies suggest okanin has antidiabetic potential by enhancing glucose uptake and improving insulin sensitivity. It also demonstrates anticancer activity by inducing apoptosis and inhibiting the growth of certain cancer cell lines, particularly in melanoma and leukemia. Additionally, okanin has been investigated for its skin-whitening effect due to its ability to inhibit tyrosinase, an enzyme involved in melanin production, suggesting applications in cosmetic formulations for hyperpigmentation treatment. Its broad pharmacological profile supports potential use in nutraceuticals, pharmaceuticals, and skincare products.