Periplogenin is primarily known for its presence in traditional medicinal plants, particularly in species of the genus *Periploca*. It exhibits significant biological activity, making it valuable in pharmacological research. One of its key applications lies in cardiovascular health, where it demonstrates cardiotonic effects by enhancing myocardial contractility, similar to digitalis-like compounds. This makes it a subject of interest in the development of treatments for heart failure and related conditions. Additionally, periplogenin has shown anti-inflammatory and immunomodulatory properties, supporting its traditional use in managing autoimmune and inflammatory disorders. Studies also indicate potential anticancer activity, where it may induce apoptosis in certain tumor cell lines, suggesting a role in oncology drug development. Due to its structural features, periplogenin serves as a useful biomarker in phytochemical analysis and quality control of herbal formulations. Its bioactivity profile continues to drive research into novel therapeutic agents derived from natural sources.