Used in research as a potent and selective inhibitor of the enzyme phosphodiesterase 2A (PDE2A), TAS4464 helps modulate intracellular signaling pathways involved in cognitive function and neuronal activity. It is primarily investigated for its potential therapeutic effects in neurodegenerative and psychiatric disorders, such as Alzheimer's disease and schizophrenia. By increasing cyclic nucleotide levels in the brain, it enhances synaptic plasticity and memory formation in preclinical models. Its high selectivity allows for targeted studies without significant off-target effects, making it a valuable tool compound in neuroscience research.