WAY-328158 is primarily used in scientific research as a selective antagonist for the 5-HT6 (serotonin 6) receptor. Its main application lies in neuroscience studies, particularly in investigating cognitive functions, memory, and neurodegenerative disorders such as Alzheimer's disease. Due to its ability to modulate serotonin signaling, it has been employed in preclinical models to assess the role of 5-HT6 receptors in learning and memory processes. It is also utilized in pharmacological studies to explore potential treatments for psychiatric conditions including schizophrenia and depression. Its high selectivity makes it a valuable tool for understanding receptor-specific effects without significant off-target activity.