Used primarily in the treatment of erectile dysfunction, particularly when linked to psychological causes. It acts as an alpha-2 adrenergic receptor antagonist, which helps increase blood flow and stimulate sexual arousal. Also investigated for use in enhancing athletic performance and promoting fat loss due to its stimulant and metabolic effects. Occasionally used in veterinary medicine to reverse sedation caused by alpha-2 agonists like xylazine. Some traditional and off-label uses include treatment of low libido and orthostatic hypotension, though evidence varies.