Used as a selective antagonist for the V1A receptor subtype of vasopressin, VAF347 is primarily employed in research settings to study vascular tone regulation and the role of vasopressin in cardiovascular function. It helps investigate conditions involving fluid balance, blood pressure control, and potential therapeutic interventions in heart failure or hypertension. Due to its specificity, it is valuable in distinguishing V1A-mediated effects from other vasopressin receptor actions in experimental models.