Dichlorotriphenylphosphorane (Ph₃PCl₂) is a specialty chemical reagent widely used in organic synthesis. It is particularly effective for converting alcohols to alkyl chlorides via chlorodehydration. It also enables the transformation of carboxylic acids to acid chlorides and serves as a dehydrating agent for converting primary amides and oximes to nitriles. Additionally, it is employed in the preparation of imidoyl chlorides from amides and in various chlorination reactions. Due to its role in facilitating selective functional group transformations, it is essential in pharmaceutical synthesis and fine chemical manufacturing.