Daidzein (≥98% HPLC) soy isoflavone for supplements; evidence-based support for antioxidant, cardiovascular, bone, and menopausal health.
Daidzein ≥98% (HPLC) soy-derived isoflavone (phytoestrogen) used in dietary supplements; researched for antioxidant, cardiovascular, bone, and menopausal support.
| Benefit |
Typical study dose* |
Key human findings |
High-quality sources |
| Antioxidant / oxidative stress |
Varies; often 20–80 mg/day total isoflavones; some trials used 40–63 mg/day daidzein |
Mixed evidence; modulation of antioxidant enzymes and markers reported in small studies |
PubMed 11880557 |
| Cardiovascular / vascular function |
Similar ranges; protocol-dependent |
Limited human data; some improvements in endothelial function/lipids |
MDPI review |
| Bone health (postmenopausal) |
Often 40–63 mg/day daidzein or mixed isoflavones |
Mixed/ modest effects on bone markers; heterogeneous trials |
Wiley review |
| Menopausal symptoms |
Varies by formulation and study |
Small, inconsistent reductions in vasomotor symptoms |
Overview |
*Dosage notes: many trials report total isoflavones; pure daidzein dosing varies by protocol and equol-producer status.
Mechanistic highlights
- SERM/ER-β modulation: selective interaction with estrogen receptors influencing gene expression
- Antioxidant pathways: affects oxidative stress signaling and enzyme systems
- Microbiome metabolite (equol): conversion in some individuals may enhance effects
Safety & practical use
- Usual supplemental range: protocol-specific; check finished-product guidance
- Upper-dose tolerance: high intakes may cause GI discomfort; monitor
- Drug interactions: caution with hormone-dependent conditions/therapies
- Special populations: consult clinician for estrogen-sensitive conditions