Daidzein
Analytical
Code: 253067
Daidzein (≥98% HPLC) soy isoflavone for supplements; evidence-based support for antioxidant, cardiovascular, bone, and menopausal health.
Daidzein
Daidzein (≥98% HPLC) soy isoflavone for supplements; evidence-based support for antioxidant, cardiovascular, bone, and menopausal health.
Daidzein ≥98% (HPLC) soy-derived isoflavone (phytoestrogen) used in dietary supplements; researched for antioxidant, cardiovascular, bone, and menopausal support.
| Benefit | Typical study dose* | Key human findings | High-quality sources |
|---|---|---|---|
| Antioxidant / oxidative stress | Varies; often 20–80 mg/day total isoflavones; some trials used 40–63 mg/day daidzein | Mixed evidence; modulation of antioxidant enzymes and markers reported in small studies | PubMed 11880557 |
| Cardiovascular / vascular function | Similar ranges; protocol-dependent | Limited human data; some improvements in endothelial function/lipids | MDPI review |
| Bone health (postmenopausal) | Often 40–63 mg/day daidzein or mixed isoflavones | Mixed/ modest effects on bone markers; heterogeneous trials | Wiley review |
| Menopausal symptoms | Varies by formulation and study | Small, inconsistent reductions in vasomotor symptoms | Overview |
*Dosage notes: many trials report total isoflavones; pure daidzein dosing varies by protocol and equol-producer status.
Mechanistic highlights
- SERM/ER-β modulation: selective interaction with estrogen receptors influencing gene expression
- Antioxidant pathways: affects oxidative stress signaling and enzyme systems
- Microbiome metabolite (equol): conversion in some individuals may enhance effects
Safety & practical use
- Usual supplemental range: protocol-specific; check finished-product guidance
- Upper-dose tolerance: high intakes may cause GI discomfort; monitor
- Drug interactions: caution with hormone-dependent conditions/therapies
- Special populations: consult clinician for estrogen-sensitive conditions
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