Heterocyclic Building Blocks

Pyridine Derivatives

Fused Pyridine Systems Substituted Pyridines Halogenated Pyridine Derivatives Pyridone Derivatives

Pyrimidine Derivatives

Pyrrolopyrimidine Derivatives Pyridopyrimidine Derivatives

Isoxazole Derivatives

Isoxazolidine Derivatives Benzisoxazole Derivatives Benzisoxazole Derivatives

Fused Furan Systems

Carbazole Derivatives

Morpholine Derivatives

Fused Heterocycles

Pyrrolopyrimidines Pyrroloquinoline Derivatives Pyrrolopyridine Derivatives

Purines

Quinazoline Derivatives

Pyrazole Derivatives

Pyrazolo[3,4-c]pyridine Derivatives Pyrazolopyridine Derivatives Pyrazole Carboxylic Acid Derivatives Pyrazolo-pyrimidine Derivatives

Imidazole Derivatives

Pyrrolidine Derivatives

Benzothiazole Derivatives

Pyrrole Derivatives

Pyrrolopyridine Derivatives

Benzimidazole Derivatives

Triazine Derivatives

Quinoxaline Derivatives

Benzofuran Derivatives

Dihydrobenzofuran Derivatives

Benzodiazepine Derivatives

Dioxane Derivatives

Azetidine Derivatives

Substituted Azetidine Derivatives

Indolizine Derivatives

Thiosemicarbazide Derivatives

Spiro cyclic Heterocycles

Oxaspiro Compounds Oxaaza Spiro Compounds

Pyridopyrimidine Derivatives

Acridine Derivatives

Indane Derivatives

Indanone Derivatives

Sulfur-Containing Heterocycles

Thiophene Derivatives Thiazole Derivatives Thiopyran Derivatives Thiadiazole Derivatives Thienopyridine Derivatives Thiomorpholine Derivatives Thiazolidine Derivatives Isothiazole Derivatives

Oxazole Derivatives

Oxadiazole Derivatives

Bridged Bicyclic Heterocycles

3,7-Diazabicyclo[3.3.1]nonane Derivatives

Benzoxazine Derivatives

Pyrazolo-pyrimidine Derivatives

Isothiazole Derivatives

Fused Bicyclic Intermediates

Cyclopenta[b]pyridine Derivatives Indane Derivatives

Pyrrolopyridine Derivatives

Dioxolane Derivatives

Thiadiazole Derivatives

Isoindole Derivatives

Pyridazinone Derivatives

Purine Derivatives

Triazolopyrimidine Derivatives

Diazepane Derivatives

Thienopyridine Derivatives

Azepine Derivatives

Benzazepines

Spiro cyclic Intermediates

Oxaaza Spiro Compounds Azaspiro Compounds

Diazepine Derivatives

Thiazolidine Derivatives

Phthalimide Derivatives

Fused Bicyclic Heterocycles

Benzofuran Derivatives Pyrrolopyridine Derivatives Quinazoline Derivatives Pyrazolo-pyrimidine Derivatives Benzimidazole Derivatives Indole Derivatives Quinoline Derivatives Pyrazolo-pyridine Derivatives Benzoxazole Derivatives Imidazothiazole Derivatives Triazolo-pyrimidine Derivatives Pyridopyrimidine Derivatives Dibenzofuran Derivatives Pyrano-pyridine Derivatives

Spirocyclic Heterocycles

Thienopyrimidine Derivatives

Aromatic Amines

Spiro cyclic Building Blocks

Oxygen-Containing Heterocycles

Pyran Derivatives Benzofuran Derivatives Dioxane Derivatives

Benzodioxole Derivatives

Hydrazine Derivatives

Benzodioxane Derivatives

Oxadiazine Derivatives

Lactams

Oxazolidine Derivatives

Maleimide Derivatives

Benzoxaborole Derivatives

Aliphatic Carboxylic Acid Derivatives

Beta-Keto Esters

Polyether Carboxylic Acids

Enamine Esters

Esters

Cyclopentanecarboxylic Acid Derivatives

Unsaturated Carboxylic Acids

Dicarboxylic Acids

Acid Chlorides

Cyclopentane Carboxylic Acids

Cyclic Unsaturated Carboxylic Acids

Hydroxy Acids

Cyclobutane Carboxylic Acids

Malonic Acid Derivatives

Fluorinated Aliphatic Esters

Cyclopentene Carboxylic Acids

Fluorinated Pharmaceutical Intermediates

Aromatic Ethers

Aromatic Carboxylic Acid Derivatives

Aromatic Halides

Isotopically Labeled Pharmaceutical Intermediates

Ophthalmic Agents

Veterinary Pharmaceuticals

Reproductive Agents

Antiparasitic Agents

Antibiotics

Aminoglycoside Antibiotics

Sedatives and Tranquilizers

Appetite Stimulants

Growth Promoters

Diuretics

Cardiovascular Agents

Cardiac Stimulants

Anti-Inflammatory and Analgesic Agents

Bone Metabolism Modulators

Anesthetic Adjuncts

Sedative Agents

Immunomodulators

Hormonal Agents

Progestins

Estrogens

Androgen Inhibitors

Androgens

Corticosteroids

GnRH Agonists

GnRH Antagonists

Selective Estrogen Receptor Modulators

Vitamin D Derivatives

Somatostatin Analogs

Thyroid Hormone Receptor Agonists

Kisspeptin Receptor Agonists

Steroid Enzyme Substrates

Gut Hormone Analogs

Vasopressin Receptor Antagonists

Thyroid Hormone Analogs

Vasopressin Receptor Agonists

Growth Hormone Secretagogues

Prostaglandin Derivatives

Steroid Precursors

Aromatic Amine Salts

Isothiocyanate Reagents

Excipients

pH Adjusters

Thickening Agents

Stabilizing Agents

Carbohydrate Excipients

Buffering Agents

Solubilizing Agents

Cyclodextrins

Preservatives

Calcium Salts

Emulsifiers

Humectants and Plasticizers

Neurological Intermediates

Antipsychotic Intermediates

Analgesic and Antipyretic Agents

Antidepressants

Psychostimulants and Nootropics

Antiepileptic Agents

GABA Receptor Ligands

Neuroprotective Agents

Dopamine Receptor Ligands

Serotonin Receptor Ligands

Alzheimer's Disease Intermediates

Hematological Agents

Thrombopoietin Receptor Agonists

Histamine Receptor Ligands

Local Anesthetics

Neurotransmitter Receptor Modulators

Nicotinic Acetylcholine Receptor Modulators Dopamine Receptor Ligands Serotonin Receptor Modulators GABA Receptor Ligands Opioid Receptor Modulators Sigma Receptor Antagonists Opioid Receptor Ligands Histamine Receptor Ligands

Reuptake Inhibitors

Sigma-1 Receptor Agonists

Anxiolytics

Nicotinic Acetylcholine Receptor Modulators

COMT Inhibitors

Glutamate Receptor Modulators

NMDA Receptor Antagonists

Ion Channel Modulators

Orexin Receptor Antagonists

Opioid Receptor Ligands

Migraine Therapeutics

Endocannabinoid System Modulators

MAO Inhibitors

Enzyme Inhibitor Intermediates

Phosphodiesterase Inhibitors

Anticholinergic Agents

Appetite Suppressants

Antispasmodic Agents

Sedative and Anesthetic Intermediates

Neuromuscular Blocking Agents

Chiral Amines

CNS Drug Intermediates

Designer Drug Analogs

Hallucinogenic Compounds

Schizophrenia Therapeutics

Neurokinin Receptor Antagonists

Neuroprotective Intermediates

Antiemetics

Multiple Sclerosis Therapeutics

Convulsants

Heterocyclic Building Blocks

Benzimidazole Derivatives Pyrrolidine Derivatives Pyridine Derivatives Morpholine Derivatives Pyran Derivatives Indane Derivatives Isoquinoline Derivatives Indole Derivatives Spiro cyclic Heterocycles Quinoxaline Derivatives Benzisothiazole Derivatives Quinoline Derivatives Benzofuran Derivatives Thiophene Derivatives Isoxazole Derivatives Oxazepane Derivatives Imidazopyridine Derivatives Bridged Bicyclic Heterocycles Pyrazine Derivatives Pyridazine Derivatives Pyrrolizine Derivatives Diazepine Derivatives Quinuclidine Derivatives Triazole Derivatives Azepine Derivatives Fused Heterocycles Spiro cyclic Intermediates Azetidine Derivatives Pyrimidine Derivatives Quinazoline Derivatives Imidazolidine Derivatives Triazolopyridine Derivatives Benzoxazine Derivatives Benzoxazole Derivatives Thiazole Derivatives Sulfur-Containing Heterocycles Benzodioxane Derivatives Benzothiazole Derivatives Fused Bicyclic Heterocycles Spirocyclic Heterocycles Pyrrole Derivatives Cyclopropane Derivatives Benzisoxazole Derivatives Spiro cyclic Building Blocks Fused Bicyclic Intermediates Diazepane Derivatives Oxygen-Containing Heterocycles Pyrazole Derivatives

Aromatic Alcohols

Halogenated Aromatic Alcohols

Adamantane Derivatives

Phenethylamine Derivatives

Anticonvulsants

Neurotransmitter Precursors

Imidazopyrazine Derivatives

Antipsychotics

Naphthalene Derivatives

Tetralone Derivatives

Choline Derivatives

Hepatoprotective Intermediates

Serotonin Receptor Modulators

Adrenergic Receptor Ligands

Alzheimer's Disease Modulators

Antihistamine Intermediates

NAChR Modulators

Spiro cyclic CNS Intermediates

Nitrile Intermediates

Benzonitrile Derivatives

Anticonvulsant Agents

Aromatic Amine Intermediates

Cognitive Enhancers

Sigma Receptor Antagonists

Adenosine Receptor Ligands

Muscle Relaxants

Ketone Intermediates

Aromatic Ketones Amino Ketones

Amino Acid Derivatives

Aromatic Amines

Halogenated Aniline Derivatives Halogenated Aniline Derivatives Halogenated Aniline Derivatives Aniline Derivatives Benzylamine Derivatives Aniline Derivatives Aromatic Diamines Benzylamine Derivatives

Enzyme Inhibitors

FAAH Inhibitors Phosphodiesterase Inhibitors

Hydrazine Derivatives

Schizophrenia Treatments

Cyclopropylamine Derivatives

Adrenergic Receptor Modulators

Amine Intermediates

Chiral Pharmaceutical Intermediates

Chiral Amines Chiral Amino Acids

Indane Derivatives

Indanone Derivatives

Amide Intermediates

Aliphatic Amine Intermediates

Organic Synthesis Intermediates

Aromatic Ketones Nitrile Intermediates Aromatic Aldehydes Ketone Intermediates Esters

Aliphatic Amines

Amino Ester Intermediates

Fused Bicyclic Intermediates

Indane Derivatives

Bicyclic Building Blocks

Cardiovascular Intermediates

Calcium Channel Blockers

Angiotensin II Receptor Blockers

Antiplatelet Agents

HMG-CoA Reductase Inhibitors

Vasodilator Intermediates

ACE Inhibitors

Antiarrhythmic Agents

Neprilysin Inhibitors

Renin Inhibitors

PCSK9 Inhibitors

Beta Blocker Intermediates

Endothelin Receptor Antagonists

Anticoagulants

Factor Xa Inhibitors Coumarin Derivatives

Anticoagulant Reversal Agents

Lipid-Lowering Agents

Thyroid Hormone Receptor Agonists ATP Citrate Lyase Inhibitors MTP Inhibitors CETP Inhibitors

Imidazoline Receptor Agonists

Adrenergic Receptor Agonists

Gap Junction Modifiers

Diuretics

Mineralocorticoid Receptor Antagonists

Cardiac Glycosides

PDE5 Inhibitors

Heterocyclic Building Blocks

Piperidine Derivatives Pyran Derivatives Sulfur-Containing Heterocycles Pyridazinone Derivatives Pyridazine Derivatives

Adrenergic Receptor Antagonists

Vitamin K and Anticoagulant Intermediates

Centrally Acting Antihypertensives

Aldosterone Synthase Inhibitors

Factor Xa Inhibitors

Thrombin Inhibitors

Sodium-Hydrogen Exchanger Inhibitors

CETP Inhibitors

Oncology Drug Intermediates

Targeted Cancer Therapy Agents

ADC Linkers

ADC Payloads

Radiosensitizers

Alkylating Agents

Selective Estrogen Receptor Degraders

Antimetabolites

Enzyme Inhibitor Intermediates

HDAC Inhibitors Kinase Inhibitors PARP Inhibitors Topoisomerase Inhibitors Cancer Immunotherapy Agents IDH Inhibitors Protease Inhibitors

Selective Estrogen Receptor Modulators

Cancer Immunotherapy Agents

Cytoprotective Agents

PROTAC Intermediates

Cytotoxic Natural Products

Heterocyclic Building Blocks

Pyridine Derivatives Isoquinoline Derivatives Pyrimidine Derivatives Isoxazole Derivatives Indole Derivatives Purine Derivatives

Immunomodulatory Agents

Adenosine Receptor Antagonists

Nucleoside Analogs

Photosensitizers

Antibiotics

Anti-Tuberculosis Agents

Tetracycline Antibiotics

Oxazolidinone Intermediates

Beta-Lactamase Inhibitors

Glycopeptide Antibiotics

Macrolide Intermediates

Antiseptics and Disinfectants

Antifungal Agents

Bile Acid Derivatives

Natural Product Derivatives

Antioxidant Natural Products

Hepatoprotective Intermediates

Amino Acid Derivatives

Protected Amino Acids

Chiral Amino Acids

Antiviral Intermediates

Herpesvirus Inhibitors

Influenza Antivirals

Anti-Inflammatory Intermediates

Heterocyclic Building Blocks

NSAID Derivatives

Aromatic Alcohols

Halogenated Aromatic Alcohols

Antiparasitic Agents

Reproductive Agents

Drug Discovery Reagents

Neurological Research Reagents

Heterocyclic Building Blocks Neurotransmitter Receptor Modulators Neuroprotective Agents Organic Synthesis Intermediates

Immunomodulatory Intermediates

CB2 Receptor Antagonists

Oncology Drug Intermediates

Enzyme Inhibitor Intermediates PROTAC Intermediates Heterocyclic Building Blocks Immunomodulatory Agents Cytotoxic Natural Products

Autoimmune Research Reagents

Antiviral Research Reagents

Heterocyclic Building Blocks Nucleoside Analogs

Antimalarial Intermediates

Heterocyclic Building Blocks

Metabolic Disorder Research Tool Compounds

Enzyme Inhibitor Intermediates

Kinase Inhibitors Protease Inhibitors Phosphodiesterase Inhibitors Inflammation-Related Enzyme Inhibitors Cytochrome P450 Inhibitors

Antibacterial Research Reagents

Neurological Intermediates

Organic Synthesis Intermediates Heterocyclic Building Blocks

Organic Synthesis Intermediates

Cross-Coupling Reagents

Antiparasitic Intermediates

Heterocyclic Building Blocks

Biochemicals

Recombinant Proteins

Chalcone Derivatives

Cancer Research Tool Compounds

Drug Delivery Intermediates

Surface Modification Reagents

Signaling Pathway Reagents

Ion Channel Modulators

Natural Product Derivatives

Cardiovascular Modulators

Anti-inflammatory Intermediates

Natural Product Standards

Alkaloids Antioxidant Natural Products

Pharmacological Chaperones

Antidiabetic Intermediates

GPR40 Agonists

SGLT2 Inhibitors

DPP-4 Inhibitors

Glucagon Receptor Antagonists

Aldose Reductase Inhibitors

GLP-1 Receptor Agonists

Lipase Inhibitors

PPAR Agonists

Glucokinase Activators

Immunomodulatory Intermediates

Immunosuppressive Agents

Cancer Immunotherapy Agents

Bradykinin Receptor Antagonists

Inflammation Pathway Inhibitors

Chemokine Receptor Antagonists

Autoimmune Disease Agents

Respiratory System Agents

Antitussive Agents

Respiratory Stimulants

Antiallergic Agents

PDE4 Inhibitors

Antifibrotic Agents

Beta-2 Adrenergic Agonists

Bronchodilators

Leukotriene Receptor Antagonists

Antiemetics

Anticholinergic Agents

Metabolic Disorder Intermediates

Vitamin D Analogs

FXR Modulators

Bone Metabolism Modulators

Enzyme Inhibitor Intermediates

11β-HSD1 Inhibitors

Prolyl Hydroxylase Inhibitors

Carbonic Anhydrase Inhibitors

Kinase Inhibitors

JAK Inhibitors Heterocyclic Building Blocks

HDAC Inhibitors

ACAT Inhibitors

Myeloperoxidase Inhibitors

Beta-Lactamase Inhibitors

Sodium-Hydrogen Exchanger Inhibitors

HIF Prolyl Hydroxylase Inhibitors

Inflammation-Related Enzyme Inhibitors

Thromboxane Synthase Inhibitors

Phosphodiesterase Inhibitors

PDE4 Inhibitor Intermediates PDE10A Inhibitors

Protease Inhibitors

Organophosphorus Intermediates

Chemoprotective Agents

Antihistamine Intermediates

Genetic Disorder Modulators

Gastrointestinal Agents

Prokinetic Agents

Proton Pump Inhibitors

Cholecystokinin Antagonists

Antispasmodic Agents

Antiemetics

Anti-Ulcer Agents

PDE5 Inhibitors

Nuclear Receptor Modulators

Toxicology Antidotes

Antibacterial Agents

Gene Therapy Vectors

Dermatological Agents

Hematological Agents

Coagulation Factors

Thrombopoietin Receptor Agonists

Peptide Synthesis Reagents

Protected Dipeptides

Dipeptides

Protecting Group Reagents

Amino Acid Derivatives

Protected Amino Acids

PROTAC Intermediates

Drug Delivery Intermediates

Polyether Linkers

Penetration Enhancers

Encapsulating Agents

Surface Modification Reagents

Chiral Pharmaceutical Intermediates

Chiral Amino Alcohols

Chiral Amines

Chiral Amino Acids

Chiral Carboxylic Acids

Chiral Alcohols

Chiral Amino Acid Derivatives

Chiral Esters

Chiral Ketones

Chiral Diols

Urological Agents

Organophosphorus Intermediates

Phosphonates

Carbamates

Ketone Intermediates

Cyclic Ketones

Nitro Aromatic Derivatives

Halogenated Aliphatic Intermediates

Urea Derivatives

Halogenated Aromatic Intermediates

Nitrile Intermediates

Arylacetonitrile Derivatives

Heterocyclic Nitriles

Aromatic Aldehyde Derivatives

Aromatic Hydrocarbons

Biphenyl Derivatives

Thiol Building Blocks

Amidine Derivatives

Amide Intermediates

Benzamide Derivatives

Amidine Derivatives

Acetamide Derivatives

Sulfamides

Hydrazide Derivatives

Sulfonamide Intermediates

Thioamide Derivatives

Trifluoroacetamide Derivatives

Halogenated Aliphatic Amides

Urea Derivatives

Aromatic Amines

Halogenated Aniline Derivatives

Halogenated Aromatic Diamines

Aromatic Sulfonic Acids

Phenolic Intermediates

Halogenated Phenols

Sulfonamide Intermediates

Organic Synthesis Building Blocks

Cross-Coupling Reagents

Boronic Acids

Protecting Group Reagents

Amine Protecting Groups

Amide Intermediates

Solvents

Sulfoxide Solvents

Heterocyclic Building Blocks

Isoquinoline Derivatives

Fluorinating Reagents

Aromatic Ketones

Organic Synthesis Intermediates

Aromatic Halides

Aromatic Isocyanates

Steroidal Intermediates

Bone Metabolism Modulators

Sulfone Derivatives

AT2 Receptor Antagonists

Renal Therapeutics

Phosphate Binders

Beta-Diketone Intermediates

Contrast Agents

Analgesic and Antipyretic Agents

Endocrine Disorders

Cushing's Disease Treatments

Antifungal Intermediates

Heterocyclic Building Blocks

Benzimidazole Derivatives Imidazole Derivatives Isoxazole Derivatives Triazole Derivatives

Amine Intermediates

Vaccine Adjuvants

Oxime Derivatives

Dermatological Therapeutics

Antiparasitic Intermediates

Antimalarial Agents

Antiprotozoal Agents

Phenanthridine Derivatives

Heterocyclic Building Blocks

Antimalarial Intermediates

Heterocyclic Building Blocks

Quinoline Derivatives

API Synthesis Intermediates

Neuological Intermediates

Neurotransmitter Receptor Modulators

Cannabinoid Receptor Modulators

Anti-Inflammatory Agents

Sulfur-Containing Building Blocks

Thiol Building Blocks

Biochemicals

Enzymes

Antioxidant Agents

Antitubercular Agents

Inorganic Pharmaceuticals

Research Intermediates

Antimicrobial Intermediates

Organic Synthesis Intermediates

Heterocyclic Building Blocks

Pyrimidine Derivatives Pyridine Derivatives Oxygen-Containing Heterocycles

Hydrazines

Aliphatic Carboxylic Acid Derivatives

Esters Malonic Acid Derivatives Beta-Keto Esters

Amide Intermediates

Carbamates Sulfonamide Intermediates Acetamide Derivatives

Sulfonamide Intermediates

Aromatic Aldehydes

Acetal-Protected Aromatic Aldehydes

Cross-Coupling Reagents

Boronic Acids Borate Esters Alkyne Reagents

Ketone Intermediates

Cyclic Ketones Aliphatic Ketones Amino Ketones

Nitrile Intermediates

Benzonitrile Derivatives Arylacetonitrile Derivatives

Aromatic Sulfonic Acids

Oxime Derivatives

Aromatic Halides

Nitro Aromatic Derivatives

Sulfone Derivatives

Sulfur-Containing Building Blocks

Thiol Building Blocks

Halogenated Aliphatic Intermediates

Isothiocyanate Reagents

Sulfide Derivatives

Acid Chlorides

Aromatic Hydrocarbons

Biphenyl Derivatives Alkynes

Quinone Derivatives

Peptide Synthesis Reagents

Amino Acid Derivatives

Esters

Aliphatic Aldehydes

Organophosphorus Intermediates

Phosphonates

Antioxidant Agents

Natural Product Derivatives

Terpenoid Derivatives

Lactone Derivatives

Boron Neutron Capture Therapy Agents

Adenosine Receptor Ligands

Mineral Supplements

Guanidine Derivatives

Hydrazines

Catalysts

Organometallic Catalysts

Ruthenium Catalysts Palladium Catalysts

Amine Intermediates

Phenoxyalkyl Amines

Aromatic Diamines

Bicyclic Building Blocks

REAGENT

Ethyl 5-(aminomethyl)-1,3,4-oxadiazole-2-carboxylate 2,2,2-trifluoroacetate

≥95%

CAS:1245807-94-6

Formula:C₈H₁₀F₃N₃O₅

MW:285.18 g/mol

฿4,770.00

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REAGENT

5-(Bromomethyl)nicotinonitrile

97%

CAS:1211530-54-9

Formula:C₇H₅BrN₂

MW:197.03 g/mol

฿5,700.00

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REAGENT

5-(Chloromethyl)-3-(trifluoromethyl)-1,2,4-oxadiazole

95%

CAS:100442-49-7

Formula:C₄H₂ClF₃N₂O

MW:186.52 g/mol

฿4,644.00

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REAGENT

Methyl 5-(aminomethyl)nicotinate hydrochloride

97%

CAS:1260791-59-0

Formula:C₈H₁₁ClN₂O₂

MW:202.64 g/mol

฿5,013.00

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REAGENT

5-(4-Methoxyphenyl)-1,3,4-thiadiazol-2-amine

≥95%

CAS:1014-25-1

Formula:C₉H₉N₃OS

MW:207.25 g/mol

฿396.00

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REAGENT

5-(6-Methoxynaphthalen-2-yl)-1H-pyrazole-3-carboxylic acid

≥95%

CAS:1257877-12-5

Formula:C₁₅H₁₂N₂O₃

MW:268.27 g/mol

฿1,386.00

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REAGENT

Ethyl 5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylate

98%

CAS:99367-44-9

Formula:C₁₂H₁₂N₂O₄

MW:248.24 g/mol

฿396.00

View

REAGENT

5-(4-Chlorophenyl)oxazole-2-propionic acid

97%

CAS:23464-95-1

Formula:C₁₂H₁₀ClNO₃

MW:251.67 g/mol

฿3,735.00

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REAGENT

5-(4-Hydroxyphenyl)pyrrolidin-2-one

95%

CAS:207989-87-5

Formula:C₁₀H₁₁NO₂

MW:177.20 g/mol

฿4,374.00

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REAGENT

5-(4-Fluorophenyl)nicotinic acid

98%

CAS:364064-17-5

Formula:C₁₂H₈FNO₂

MW:217.2 g/mol

฿2,430.00

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