Bisbentiamine
a synthetic, lipid-soluble derivative of thiamine (vitamin B1). Unlike standard water-soluble forms such as thiamine hydrochloride or mononitrate, bisbentiamine offers improved bioavailability, especially at higher doses. Its lipid-soluble nature allows it to potentially cross the blood-brain barrier more effectively and achieve higher thiamine concentrations in blood and tissues, including the brain.
Sulbutiamine (e.q. Arcalion, Enerion, Sulbuxin)
a synthetic derivative of thiamine (vitamin B1), composed of two modified thiamine molecules linked together. Its main distinguishing feature is its lipid solubility, which allows it to cross the blood-brain barrier more effectively than standard thiamine.
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