1,1-Dimethoxybutane is primarily employed as a solvent and intermediate in organic synthesis, particularly in moisture-sensitive reactions requiring anhydrous conditions. It is used for the protection of carbonyl groups as an acetal and can undergo deprotection under mild acidic conditions to generate aldehydes. As a methoxy group source, it facilitates the synthesis of various organic compounds, including those in fragrance and flavor production. Its moderate volatility and polarity also make it suitable for specialty coatings and as a reaction medium in pharmaceutical manufacturing.