Tolrestat is primarily used in the treatment of diabetic neuropathy, a common complication of diabetes that affects the nerves. It works by inhibiting the enzyme aldose reductase, which plays a key role in the conversion of glucose to sorbitol. By blocking this enzyme, Tolrestat helps reduce the accumulation of sorbitol in nerve cells, which can otherwise lead to nerve damage and the symptoms associated with diabetic neuropathy, such as pain, tingling, and numbness in the extremities. Its application is particularly focused on managing and alleviating these symptoms, thereby improving the quality of life for patients with diabetes. However, its use is carefully monitored due to potential side effects and the need for precise dosing to ensure efficacy and safety.