Bis-propargyl-PEG12 is widely utilized in the field of bioconjugation and material science due to its unique properties. It serves as a versatile linker in click chemistry reactions, particularly in copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the efficient coupling of biomolecules, polymers, and nanoparticles. This chemical is instrumental in the development of drug delivery systems, where it facilitates the attachment of therapeutic agents to carriers, enhancing targeted delivery and controlled release. Additionally, it is employed in the synthesis of hydrogels and other biomaterials, providing a stable and biocompatible framework for tissue engineering and regenerative medicine applications. Its role in surface modification and functionalization of materials also makes it valuable in creating advanced coatings and sensors.