Widely used in targeted drug delivery and bioconjugation, this compound enables efficient coupling of therapeutic agents or imaging molecules to nanoparticles, liposomes, or biomolecules without the need for copper catalysts. Its DBCO group reacts selectively with azide-functionalized molecules via copper-free click chemistry, making it ideal for sensitive biological systems. The PEG(2000) spacer enhances solubility, prolongs circulation time in vivo, and reduces nonspecific interactions. Commonly employed in the development of antibody-drug conjugates, diagnostic probes, and functionalized lipid nanoparticles, especially in mRNA vaccine platforms and cancer therapeutics.