Amikacin hydrate is widely used in the medical field as an antibiotic to treat severe bacterial infections. It is particularly effective against Gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, and Klebsiella species. It is often administered in hospital settings for infections such as pneumonia, bloodstream infections, and urinary tract infections, especially when other antibiotics have failed. Amikacin hydrate is also used in the treatment of tuberculosis in combination with other antitubercular drugs. Due to its potency, it is typically given via injection, either intramuscularly or intravenously, to ensure rapid and effective delivery. Careful monitoring of kidney function and hearing is essential during treatment, as it can cause nephrotoxicity and ototoxicity.