Natural alkaloid NAD+ precursor for healthy aging, muscle strength, cognitive protection, and metabolic health in dietary supplements.
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Natural alkaloid NAD+ precursor for healthy aging, muscle strength, cognitive protection, and metabolic health in dietary supplements.
Trigonelline (Food Grade) ≥98% purity is a natural alkaloid compound that serves as a novel NAD+ precursor with proven benefits for healthy aging, muscle strength, and cognitive function.
| Benefit | Typical study dose* | Key human findings | High-quality sources |
|---|---|---|---|
| 1 Muscle Health & Strength | 5-10mg/kg/day, 30 days | Lower serum levels in sarcopenia; supplementation improved muscle strength and reduced fatigue in aged mice | Nature Metabolism 2024 |
| 2 Cognitive Protection | 5mg/kg/day, 30 days | Restored spatial learning and memory in aging models; reduced neuroinflammation (TNF-α, IL-6) | GeroScience 2023 |
| 3 Metabolic Health | 50-500mg/day | Improved glucose metabolism, enhanced insulin sensitivity, reduced HbA1c in diabetic models | PubMed 2024 |
| 4 Longevity & NAD+ Boost | 5-10mg/kg/day | Increased lifespan in C. elegans; enhanced mitochondrial oxidative phosphorylation | Nature Metabolism 2024 |
*Most human data comes from observational studies correlating serum levels with health outcomes. Animal studies used 5-10mg/kg/day orally.
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