Trigonelline (Food Grade) ≥98% purity is a natural alkaloid compound that serves as a novel NAD+ precursor with proven benefits for healthy aging, muscle strength, and cognitive function.

*Most human data comes from observational studies correlating serum levels with health outcomes. Animal studies used 5-10mg/kg/day orally.

Mechanistic highlights

1. NAD+ Precursor Activity: Trigonelline acts as a novel NAD+ precursor, enhancing cellular energy metabolism and mitochondrial function through NAD+-dependent pathways
2. Anti-inflammatory Action: Reduces pro-inflammatory cytokines (TNF-α, IL-6) in neural tissues and systemic circulation
3. Neuroprotection: Normalizes neurotransmitters (dopamine, noradrenaline, serotonin) in the hippocampus, supporting cognitive function
4. Metabolic Regulation: Enhances β-cell function, improves insulin sensitivity, and modulates glucose/lipid metabolism enzymes
5. Antioxidant Defense: Activates Nrf2 pathway, reduces oxidative stress markers, and protects against cellular damage

Safety & practical use

• Usual supplemental range: 100-500mg/day (based on coffee consumption providing 50-300mg daily)
• Upper-dose tolerance: Well-tolerated up to 1g/day; no adverse effects reported in animal studies up to 10mg/kg
• Drug interactions: May enhance effects of antidiabetic medications; monitor blood glucose if diabetic
• Natural dietary sources: Coffee (50-300mg/cup), fenugreek seeds, peas, oats
• Populations needing medical oversight: Diabetics on medication, pregnant/nursing women (limited safety data)
• Storage: Keep in airtight container away from moisture; hygroscopic compound