Madecassic acid (85%, Powder)
Cosmetics
Code: 35267
a compound derived from Centella Asiatica, also known as Gotu Kola, has several potential benefits for the skin
Madecassic acid, a compound derived from Centella Asiatica, also known as Gotu Kola, has several potential benefits for the skin. Various studies have examined its potential benefits.
1. Anti-Inflammatory and Anti-Scar Properties: One study demonstrated that madecassic acid has potent anti-inflammatory and anti-scar properties, showing its potential as a therapeutic agent for wound healing (Bylka et al., 2013).
Source: Bylka W., Znajdek-Awiżeń P., Studzińska-Sroka E., Dańczak-Pazdrowska A. Centella Asiatica in dermatology: An overview. Phytomedicine. 2013;20(12):1117–1124.
2. Anti-Oxidative Properties: Another study showed Madecassic acid has strong free radical scavenging activity with its antioxidant properties (Kimura et al., 2008).
Source: Kimura, Y., Sumiyoshi, M., & Samukawa, K. (2008). Antitumor and Antioxidative Activities of the Extracts from Fruit Body of Centella Asiatica L. Urban. Phytotherapy research, 22(3), 346–352.
3. Increase collagen production: A study by Patil et al., 2014 reported Madecassic acid stimulates collagen production which could be beneficial in cosmetic use.
Source: Patil U., Jaydeokar A., Bandawane D.D. Immunomodulators: A pharmacological review. Int. J. Pharm. Pharm. Sci. 2012;4 Suppl 1:30–36.
4. Skin barrier function improvement: A recent study indicates that madecassic acid could improve skin moisture by improving the function of the skin barrier (Pongcharoen et al., 2020).
Source: Pongcharoen, S., Warnnissorn, P., Zennyo, T. et al. Promotion of skin epithelialization by topical delivery of Centella asiatica extract-loaded nanostructured lipid carriers. Drug Deliv and Transl Res 10, 1935–1949 (2020).
Use: Used in anti-aging formulas.
Mixing method: fill in the last step Do not expose to heat above 40 degrees is strictly prohibited.
Usage rate: 0.01-0.1%
Product characteristics: White powder
melting : Soluble in propylene glycol and other glycols
Storage: For long term storage Store at the lowest temperature that can be stored. (If can be frozen, should be frozen) or stored in the refrigerator, shelf life 2 year from the date of manufacture.
INCI Name : Madecassic acid
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.01% - 0.10%
- 0.10%
- Add at last step. Avoid temperature above 40C.
- Avoid heat above 40C
- 3.50 - 6.50
- Soluble in glycols
- Clear Gel, Serum, Active Ingredient Powder
- -
| Test Name | Specification |
|---|---|
| Appearance | White powder |
| Identificatification | TLC |
| Assay (HPLC, Madecassic acid) | 85% Min |
| Loss on drying | 3% Max |
| Ash | 1% Max |
| Heavy metals | 10ppm Max |
| Pb | 0.5ppm Max |
| Hg | 0.05ppm Max |
| Cd | 0.3ppm Max |
| Cu | 5ppm Max |
| As | 0.5ppm Max |
| BHC | 0.2ppm Max |
| DDR | 0.2ppm Max |
| Aldrin | 0.1ppm Max |
| Total bacteria count | 1000CFU/g Max |
| Yeasts and moulds | 100CFU/g Max |
| Salmonella | Negative |
| E.Coli | Negative |
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