Pre-D3™ (7-dehydrocholesterol Water Soluble)

Pre-D3™ (7-dehydrocholesterol Water Soluble)
Cosmetics Code: 127713

7-dehydrocholesterol is a type that can be directly dissolved in water, which is a precursor of the skin in creating Vitamin D3.

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Pre-D3™ (7-dehydrocholesterol Water Soluble)

7-dehydrocholesterol is a type that can be directly dissolved in water, which is a precursor of the skin in creating Vitamin D3.



Key benefit What the research shows Representative study (text citation)
Improves skin hydration and barrier in xerosis Daily use of a 7-DHC + vitamin D₃ cream for 4 weeks raised corneometer hydration values, lowered transepidermal water loss, eased pruritus and was well-tolerated in elderly women with dry, itchy skin. Yahya YF et al., “Efficiency of 7-dehydrocholesterol vitamin-D₃ complex cream for xerosis and pruritus in elderly women,” J Gen Proced Dermatol Venereol Indones 8(1), 2024. (scholarhub.ui.ac.id)
Raises systemic vitamin D status through the skin A randomized pilot trial showed that an aloe-based cream delivering 5 000 IU vitamin D₃ + 7-DHC daily lifted mean serum 25-hydroxy-vitamin D from 12 ng mL⁻¹ to 38 ng mL⁻¹ after 3 months without safety issues. Sadat-Ali M et al., “Topical Delivery of Vitamin D₃: A Randomized Controlled Pilot Study,” Int J Biomed Sci 10(1), 2014. (pmc.ncbi.nlm.nih.gov)
Supports keratinocyte differentiation, antimicrobial peptide expression and overall barrier homeostasis UVB-driven conversion of epidermal 7-DHC to vitamin D₃ and its active metabolites in a human skin-equivalent model generated 1α,25-dihydroxy-vitamin D₃ that regulates cornified-envelope proteins and innate-immune peptides (LL-37, β-defensin-2). Lehmann B et al., “UVB-induced conversion of 7-dehydrocholesterol to 1α,25-dihydroxyvitamin D₃ in an in vitro human skin equivalent,” J Invest Dermatol 117(5), 2001. (pubmed.ncbi.nlm.nih.gov)
Acts as an intrinsic narrow-band UVB filter while permitting controlled vitamin D synthesis 7-DHC shows three absorption maxima at 270, 280 and 295 nm, scavenging DNA-damaging photons and plateauing after ~15 % conversion, thereby balancing photoprotection with vitamin D production. Arnold F et al., “Metabolism of Vitamin D in Skin: Benefits for Skin-Care Applications,” Cosmetics & Toiletries 2013. (cosmeticsandtoiletries.com)
Contributes to anti-inflammatory and wound-healing effects via local vitamin D metabolites Topical calcitriol (generated downstream of 7-DHC) reduces keratinocyte hyper-proliferation in plaque psoriasis and accelerates re-epithelialisation in surgical wounds. Linus Pauling Institute, “Vitamin D and Skin Health” (review), Oregon State University Micronutrient Information Center, 2016. (lpi.oregonstate.edu)
Formulation caveat – pro-oxidant under UVA Substituting membrane cholesterol with 7-DHC in keratinocytes amplified UVA-induced reactive oxygen species and PGE₂ via NADPH-oxidase and mitochondrial pathways; antioxidants are therefore recommended in 7-DHC–rich topicals. Valencia A et al., “7-Dehydrocholesterol enhances UVA-induced oxidative stress in keratinocytes,” Free Radic Biol Med 41(11), 2006. (pubmed.ncbi.nlm.nih.gov)




Practical formulation tips

  • Combine 7-DHC with lipid-compatible antioxidants (eg, tocopherol, silymarin) to counteract UVA-triggered ROS.

  • Encapsulate in light-protected, oxygen-controlled delivery systems (liposomes, polymeric nanocapsules) to maintain stability until application.

  • Pair with broad-spectrum UV filters that spare the 290–305 nm window, allowing photoconversion to vitamin D₃ while shielding deeper UVA.

  • Optimal skin concentration ranges in commercial creams are 0.05 – 0.2 % (of pure 7-dehydrocholesterol), balancing efficacy with oxidative safety.






How to use: Ingredients in moisturizers for sensitive skin, dry skin, premature aging skin, premature aging skin.

Mixing method: Mix the oil part in the formula. Avoid heat exceeding 40C.

Usage rate: 0.1-3%

Product characteristics: Light-colored clear liquid

Solubility: Soluble in water.

Storage method: Shelf life: 24 months. Please store in a refrigerator at 6 °C -8 °C. Mixed cosmetics should be stored in the refrigerator.

INCI Name : Water, Cyclodextrin, 7-dehydrocholesterol, Glycerin, Phenoxyethanol, Chlorphenesin


  • Room (25-40C)
  • 24 Months from manufacturing or testing date. (Current Lot will expire: 03/2027)
  • 0.10% - 3.00%
  • 2.00%
  • Add into oil phase. Heat tolerant.
  • Avoid heat above 90C
  • 3.50 - 6.50
  • Soluble in Water
  • -
Test Name Specification
Appearance Light colored liquid
Odor Characteristics
Content of 7-Dehydrocholesterol (w/w%) 4.5-5.5
Total Plate Count ≤ 100 CFU/g
Yeast & Mold ≤ 10 CFU/g
E. coli Negative/g
Salmonella Negative/25g

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Pre-D3™ (7-dehydrocholesterol Water Soluble)

7-dehydrocholesterol is a type that can be directly dissolved in water, which is a precursor of the skin in creating Vitamin D3.

Pre-D3™ (7-dehydrocholesterol Water Soluble)

7-dehydrocholesterol is a type that can be directly dissolved in water, which is a precursor of the skin in creating Vitamin D3.



Key benefit What the research shows Representative study (text citation)
Improves skin hydration and barrier in xerosis Daily use of a 7-DHC + vitamin D₃ cream for 4 weeks raised corneometer hydration values, lowered transepidermal water loss, eased pruritus and was well-tolerated in elderly women with dry, itchy skin. Yahya YF et al., “Efficiency of 7-dehydrocholesterol vitamin-D₃ complex cream for xerosis and pruritus in elderly women,” J Gen Proced Dermatol Venereol Indones 8(1), 2024. (scholarhub.ui.ac.id)
Raises systemic vitamin D status through the skin A randomized pilot trial showed that an aloe-based cream delivering 5 000 IU vitamin D₃ + 7-DHC daily lifted mean serum 25-hydroxy-vitamin D from 12 ng mL⁻¹ to 38 ng mL⁻¹ after 3 months without safety issues. Sadat-Ali M et al., “Topical Delivery of Vitamin D₃: A Randomized Controlled Pilot Study,” Int J Biomed Sci 10(1), 2014. (pmc.ncbi.nlm.nih.gov)
Supports keratinocyte differentiation, antimicrobial peptide expression and overall barrier homeostasis UVB-driven conversion of epidermal 7-DHC to vitamin D₃ and its active metabolites in a human skin-equivalent model generated 1α,25-dihydroxy-vitamin D₃ that regulates cornified-envelope proteins and innate-immune peptides (LL-37, β-defensin-2). Lehmann B et al., “UVB-induced conversion of 7-dehydrocholesterol to 1α,25-dihydroxyvitamin D₃ in an in vitro human skin equivalent,” J Invest Dermatol 117(5), 2001. (pubmed.ncbi.nlm.nih.gov)
Acts as an intrinsic narrow-band UVB filter while permitting controlled vitamin D synthesis 7-DHC shows three absorption maxima at 270, 280 and 295 nm, scavenging DNA-damaging photons and plateauing after ~15 % conversion, thereby balancing photoprotection with vitamin D production. Arnold F et al., “Metabolism of Vitamin D in Skin: Benefits for Skin-Care Applications,” Cosmetics & Toiletries 2013. (cosmeticsandtoiletries.com)
Contributes to anti-inflammatory and wound-healing effects via local vitamin D metabolites Topical calcitriol (generated downstream of 7-DHC) reduces keratinocyte hyper-proliferation in plaque psoriasis and accelerates re-epithelialisation in surgical wounds. Linus Pauling Institute, “Vitamin D and Skin Health” (review), Oregon State University Micronutrient Information Center, 2016. (lpi.oregonstate.edu)
Formulation caveat – pro-oxidant under UVA Substituting membrane cholesterol with 7-DHC in keratinocytes amplified UVA-induced reactive oxygen species and PGE₂ via NADPH-oxidase and mitochondrial pathways; antioxidants are therefore recommended in 7-DHC–rich topicals. Valencia A et al., “7-Dehydrocholesterol enhances UVA-induced oxidative stress in keratinocytes,” Free Radic Biol Med 41(11), 2006. (pubmed.ncbi.nlm.nih.gov)




Practical formulation tips






How to use: Ingredients in moisturizers for sensitive skin, dry skin, premature aging skin, premature aging skin.

Mixing method: Mix the oil part in the formula. Avoid heat exceeding 40C.

Usage rate: 0.1-3%

Product characteristics: Light-colored clear liquid

Solubility: Soluble in water.

Storage method: Shelf life: 24 months. Please store in a refrigerator at 6 °C -8 °C. Mixed cosmetics should be stored in the refrigerator.

INCI Name : Water, Cyclodextrin, 7-dehydrocholesterol, Glycerin, Phenoxyethanol, Chlorphenesin

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