MI-2
≥98%
Reagent
Code: #101386
CAS Number
1271738-62-5
blur_circular Chemical Specifications
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Molecular Information
Weight
375.55 g/mol
Formula
C₁₈H₂₅N₅S₂
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Storage & Handling
Storage
-20°C
description Product Description
MI-2 is primarily utilized in research settings to study its interaction with the NOTCH signaling pathway, which plays a crucial role in cellular differentiation, proliferation, and apoptosis. It is particularly investigated for its potential to inhibit the activity of the MAML1 protein, a key coactivator in the NOTCH pathway. This inhibition is of significant interest in cancer research, as aberrant NOTCH signaling is implicated in various malignancies. By targeting this pathway, MI-2 serves as a tool to explore therapeutic strategies for cancers where NOTCH signaling is dysregulated, such as T-cell acute lymphoblastic leukemia (T-ALL) and other NOTCH-dependent tumors. Additionally, it aids in understanding the broader biological mechanisms influenced by NOTCH signaling in both normal and pathological conditions.
format_list_bulleted Product Specification
Test Parameter | Specification |
---|---|
Appearance | Yellow Solid |
Purity (%) | 98-100 |
NMR | Consistent with Structure |
Infrared Spectrum | Conforms To Structure |
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MI-2
MI-2 is primarily utilized in research settings to study its interaction with the NOTCH signaling pathway, which plays a crucial role in cellular differentiation, proliferation, and apoptosis. It is particularly investigated for its potential to inhibit the activity of the MAML1 protein, a key coactivator in the NOTCH pathway. This inhibition is of significant interest in cancer research, as aberrant NOTCH signaling is implicated in various malignancies. By targeting this pathway, MI-2 serves as a tool to explore therapeutic strategies for cancers where NOTCH signaling is dysregulated, such as T-cell acute lymphoblastic leukemia (T-ALL) and other NOTCH-dependent tumors. Additionally, it aids in understanding the broader biological mechanisms influenced by NOTCH signaling in both normal and pathological conditions.
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